制药系
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王海峰,博士,讲师,硕士生导师

地址:湖北省武汉市东湖新技术开发区光谷一路206号

邮编:430205

E-mail: skytacle@139.com

教育背景

2013.9-2017.7,复旦大学,化学系,博士

2005.9-2008.7,西北师范大学,化学化工学院,硕士

工作履历

2019.12-至今,银河国际在线登录,银河国际在线登录,讲师

2017.7-2019.11, 周口师范学院,化学化工学院,讲师

2008.7-2013.7,制药企业,从事新药开发和药物合成工艺研发

研究领域

1.天然产物和手性药物合成研究: 天然甾体类化合物和抗病毒药物的不对称合成

2.基于微通道连续流动化学的药物合成工艺研究:高端磷系化学品的绿色制造

3.卡宾化学新反应研究:基于卡宾前体的功能性有机分子合成研究

科研项目

1.湖北省自然科学基金一般面上项目, 主持,

2.湖北省教育厅科学研究计划指导性项目,主持

3.河南省科技厅科技攻关项目,主持

4.东华理工大学江西省合成化学重点实验室开放基金项目,主持

学术成果

部分研究论文:

(1) Huan Li, Zhimin Xia, Lewan Li, Jie Zeng, Jian Lv, Haifeng Wang*, Shuangxi Gu*, and Fener Chen*. Regioselective Cleavage and Reconffguration of C−S Bonds with Diazo Compounds. Org. Lett. 2024, 26, 8405-8409. (中科院分区: 一区)

(2) Lewan Li, Mengxiang Luo, Shuntian Liu, Jian Lv, Jie Zeng, Qiongjiao Yan, Jie Liao, Haifeng Wang*, Shuangxi Gu*. Rapid and General Access to α‐Halogenated Carbonyl Compounds Using Amidine Halide Salts as Halogen Sources under Mild Conditions. Eur. J. Org. Chem. 2024, accepted articles, DOI: 10.1002/ejoc.202401111. (中科院分区:三区)

(3) Shuqi Zhou, Chunyan Li, Jie Zeng, Jian Lv, Jie Liao, Haifeng Wang*, Qiongjiao Yan* and Shuangxi Gu*. Al(OTf)3‑Catalyzed Regioselective N2−Arylation of Tetrazoles with Diazo Compounds. J. Org. Chem. 2024, 89, 7859-7864. (中科院分区:二区)

(4) Mengxiang Luo, Lewan Li, Shixin Chen, Qiongjiao Yan, Jian Lv, Jie Zeng, Haifeng Wang*, Shuangxi Gu* and Fener Chen*. Synthesis of 2,4-Disubstituted Oxazoles and Thiazoles via Brønsted Acid-Catalyzed Cyclization of α‑diazoketones with Amides. J. Org. Chem. 2024, 89, 7, 5038-5048. (中科院分区:二区)

(5) Chunyan Li, Tonghui Zhang, Menghua Dong, Lewan Li, Huan Li, Jie Zeng, Jian Lv, Haifeng Wang*, Shuangxi Gu.* Brønsted acid-catalyzed selective alkylation of tetrazoles with acetone. Tetrahedron Lett. 2024, 151, 155327. (中科院分区:四区)

(6) Zhimin Xia, Chunyan Li, Mengxiang Luo, Shuangxi Gua, Qiongjiao Yan, jian Lv, jie Zeng, Haifeng Wang*. Substrate-Controlled Regioselective Alkylation of 4-Hydroxycoumarin with Diazo Compounds through TfOH Catalysis. Synlett, 2024, 35,1584-1590. (中科院分区:三区)

(7) Jingru Jin, Chunyan Li, Rui Wang, Zhimin Xia, Qiongjiao Yan, Wei Wang, ShuangXi Gu, Haifeng Wang*, and Fener Chen*. Chemodivergent Synthesis of Sulfonamide and Sulfones from N-Tosylhydrazones by Switching Catalyst and Temperature. Org. Lett. 2023, 25, 32, 6012-6017. (中科院分区:一区)

(8) Chunyan Li, Rui Wang, Li Huang, Jiale Chen, Jingru Jin, Qiongjiao Yan, Wei Wang, Haifeng Wang*, and Fener Chen*. TfOH-Catalyzed Regioselective S–H Insertion of Cyclic Thioamide Derivatives with Diazo Compounds at Room Temperature. J. Org. Chem. 2023, 88, 7, 4452-4457. (中科院分区:二区)

(9) Zhewei Yan, Hangli He, Dabiao Yuan, Qiongjiao Yan, Wei Wang, Haipeng Jiang, Haifeng Wang*, Fener Chen*. Regioselective O-Alkylation of 2-Pyridones by TfOH-catalyzed carbenoid insertion. Chem. Commun. 2023, 59, 106-109. (中科院分区:二区)

(10) Mengxiang Luo, Rui Wang, Yang Li, Jiahao Gong, Shuangxi Gu, Qiongjiao Yan, Jian Lv, Jie Zeng, Wei Wang, Haifeng Wang*, Fener Chen*. TfOH-Catalyzed Regioselective Alkylation of Hydroxybenzotriazole with Diazo Compounds and Further Base Facilitated Elimination under Batch and Flow Conditions. Asian J. Org. Chem. 2023, e202300511. (中科院分区:三区)

(11) Rui Wang, Hangli He, Qiongjiao Yan, Wei Wang, Haifeng Wang*, Fener Chen*. TfOH-Catalyzed Three-Component Synthesis of Dithiocarbamates from α-Diazoesters under Continuous Flow Conditions. J. Flow Chem. 2023, 13, 1-8. (中科院分区:三区)

(12) Hangli He, Jingyu Yan, Jingru Jin, Zhewei Yan, Qiongjiao Yan, Wei Wang, Haipeng Jiang, Haifeng Wang* and Fener Chen*. TfOH-catalyzed regioselective N2-Alkylation of indazoles with diazo compounds. Chem. Commun. 2022, 58, 6429-6432. (中科院分区:二区)

(13) Hangli He, Zhewei Yan, Qiongjiao Yan, Wei Wang, Haifeng Wang*, Fener Chen*. Solvent Controlled Three-Component Reaction of Diazo Compounds for the Synthesis of Hydrazone Compounds under Brønsted Acid Catalysis, New J. Chem. 2022, 46, 22513-22517. (中科院分区:三区)

(14) 葛 锐, 朱园园, 王海峰*, 古双喜*. 手性化合物绝对构型确定的方法与应用, Chin. J. Org. Chem. 2022, 42, 424-433. (中科院分区:三区)

(15) Haifeng Wang*, Xiangli Sun, Manman Hu, Xiaoyi Zhang, Lele Xie, Shuangxi Gu*. Bromination of α-diazo Phenylacetate Derivatives Using Cobalt (II) Bromid, Adv. Synth. & Catal. 2020, 362, 3347-3351.

(16) Haifeng Wang, Shuangxi Gu, Qiongjiao Yan, Li Ding, Fen-Er Chen*. Asymmetric Catalysis in Synthetic Strategies for Chiral Benzothiazepines. Green Synthesis and Catalysis, 2020, 12-25.

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