龙思会，博士，教授
地址：中国.湖北.武汉.东湖新技术开发区光谷一路206号银河国际在线登录
邮编：430205
Email：sihuilong@wit.edu.cn; 1738054890@qq.com
电话：17762502329
教育背景
2000 - 2006 美国肯塔基大学化学系（Department of Chemistry, University of Kentucky），博士
1997 - 2000 武汉大学化学系，硕士
1993 – 1997 武汉大学化学系，学士
工作履历
2014.1- 银河国际在线登录，特聘教授, 教授
2012-2013 美国俄亥俄州立大学化学与生物化学系(Department of Chemistry and Biochemistry, Ohio State University) 博士后
2011-2012 美国俄亥俄州立大学药学院(College of Pharmacy, Ohio State University) 博士后
2006-2011 美国肯塔基大学药学院 (College of Pharmacy, University of Kentucky) 博士后
学术兼职
美国化学会（ACS）和美国药剂科学家协会（AAPS）会员
研究领域
药物化学：抗肿瘤药物的设计，合成(design, synthesis and evaluation of anticancer drugs)；抗生素类药物的设计，合成(design, synthesis and evaluation of antibiotics)；天然多肽的模拟(peptidomimicry)
药物制剂：药物分子的多晶型(polymorphism of APIs）,预制剂(preformulation), 药物输送体系(drug delivery systems)
有机化学：有机合成(organic synthesis)
代表性论文（专利，专著）
2024
Chenxin Liu, Haiyan Chen, Shuang Cao , Ju Guo , Ziwei Liu, Sihui Long “RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective”, Bioorganic Chemistry 2024, 143, 107044
2023
Junliang Zhu, Quan Dai, Ren Zhu, Sihui Long, Wenying Yu “Advances in research on drugs for treatment of COVID-19”, Progress in Pharmaceutical Sciences 2023, 47(7), 519-531
Yuexiao Hu, Ziwei Liu, Gaofeng Zha, Sihui Long, M. B. Sridhara, Kothanahally S. Sharath Kumar, Kadalipura P. Rakesh “Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) study” Process Biochemistry 2023 ASAP
Wanru Gao, Yuping Li, Yunping Zhoujin, Qun Zeng, Liwen Fang, Sean Parkin, Tonglei Li, Shigang Ruan, Sihui Long “A peptoid-like approach led to lactam-lactam dimer formation in 2-hydroxy-N-alkyl-N-phenyl-nicotinamides and their polymorphism and solvatomorphism” ACS Omega, ASAP
Jing Wang, Sihui Long, Ziwei Liu, Kadalipura P. Rakesh, Rameshwari Verma, Santosh Kumar Verma, Kothanahally S. Sharath Kumar “Structure-activity relationship studies of thiazole agents with potential anti methicillin-resistance Staphylococcus aureus (MRSA) activity” Process Biochemistry 2023, 132, 13-29
Siyu Chen, Jingliang Cui, Haiyan Chen, Bo Yu, Sihui Long “Recent progress in degradation of membrane proteins by PROTACs and alternative targeted protein degradation techniques” European Journal of Medicinal Chemistry, 2023, 262, 115911
Xiaoting Liu, Jingliang Cui, Qun Zeng, Liwen Fang, Peng-Yu Liang, Pan-Pan Zhou, Sean Parkin , Tonglei Li, Shigang Ruan, Sihui Long “Solvatomorphism and first-time observation of acid-acid catemer in 4- phenylamino-benzoic acids” RSC Advances, 2023, 13, 21021-21035
Guimiao Tian, Qiuyi Song, Ziwei Liu, Ju Guo, Shuang Cao, Sihui Long “Recent advances in 1,2,3- and 1,2,4-triazole hybrids as antimicrobials and their SAR: A critical review” European Journal of Medicinal Chemistry, 2023,259, 115603
Jidan Zhu, Siyu Chen, Ziwei Liu, Ju Guo, Shuang Cao, Sihui Long “Recent advances in anticancer peptoids” Bioorganic Chemistry 2023, 139, 106686
Yuping Li, Yang Tao, Yunping Zhoujin, Fang Zhao, Peng-Yu Liang,
Sean Parkin, Tonglei Li, Pan-Pan Zhou and Sihui Long “π–π stacking in the polymorphism of 2-(naphthalenylamino)-nicotinic acids and a comparison with their analogues” CrystEngComm, 2023, 25, 432–443
Zhoujin, Y.; Li, Y.; Liang, P-Y.; Zhou, P-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. “anti/gauche Conformations lead to the polymorphism in homologous phenylalkylamino-nicotinic acids” Crystal Growth & Design 2023, 23, 3154-3163
2022
Li, J.; Wu, K.; Li, X.; Long, S.; Zhou, Z.; Zhao, Y.; Jia, R.; Song, P.; Liu, J.; Liu, B. “Quantifying induction/inhibition effects on fuzuloparib using a Physiologically Based Pharmaco-Kinetic (PBPK) model” Journal of Clinical and Experimental Pathology 2022, 105(1), 229
Zhu, R.; He, Q.; Li, Z.; Ren, Y.; Liao, Y.; Zhang, Z.; Dai, Q.; Wan, C.; Long, S.; Kong, L.; Fan, W.; Yu, W. “ROS-cleavable diselenide nanomedicine for NIR-controlled drug release and on-demand synergistic chemo-photodynamic therapy” Acta Biomaterialia, 2022, 153(22), 442
Zhao, X.; Liu, Z.; Liu, H.; Guo, J.; Long, S. “Hybrid molecules based on caffeic acid as potential therapeutics: A focused review” European Journal of Medicinal Chemistry, 2022, 243, 114745
Zhoujin, Y.; Li, Y.; Liang, P.-Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Yu, F.; Long, S. “Effect of homologation on the polymorphism of anthranilic acids”, Crystal Growth & Design, 2022, 22(10), 6207
Dong, B.; Liu, Y.; Yang, P.; Sang, D.; Tian, J.; Li, L.; Long, S. “Denitrogenative cleavage of benzotriazoles and benzotriazinones, and selective N-desulfonylation of benzotriazoles by aluminum halides”, Tetrahedron Letters, 2022, 103,153965
Xie, D.; Xu, X.; Long, S.; Tang, X-Y.; Wang, L. “Synthesis of (2-(quinolin-2-yl)phenyl)carbamates by a one-pot Friedel-Crafts reaction/oxidative Umpolung Aza-Grob Fragmentation sequence” J. Org. Chem. 2022, 87(12), 7852
Tao, Y.; Liu, X.; Zhoujin, Y.; Zhou, P.-P.; Parkin, S.; Li, T.; Guo, J.; Yu, F.; Long, S. “Conformational flexibility and substitution pattern lead to polymorphism of 3-methyl-2-(phenylamino)benzoic acid” CrystEngComm, 2022, 24, 3217
Zhoujin, Y.; Li, Y., Zhang, M.; Parkin, S.; Guo, J.; Li, T.; Yu, F.; Long, S. “Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems” CrystEngComm 2022, 24, 681
Zhoujin, Y.; Tao, Y.; Zhou, P.; Parkin, S. R.; Li, T.; Guo, J.; Yu, F.; Long, S. “Double substitution leads to a highly polymorphic system in 5-methyl-2-m-tolylamino-benzoic acid” CrystEngComm, 2022, 24, 95
2021
Zhoujin, Y.; Yang, X.; Zhang, M.; Guo, J.; Parkin, S.; Li, T.; Yu, F.; Long, S. “Synthon polymorphism and π-π stacking in N-phenyl-2-hydroxynicotinanilides” Crystal Growth & Design, 2021, 21, 6155
Ren,Y.; Li, S.; Zhu, R.; Wan, C.; Song, D.; Zhu, J.; Cai, G.; Long, S.; Kong, L. Yu, W. “Discovery of STAT3 and Histone Deacetylase (HDAC) dual-pathway inhibitors for the treatment of solid cancer”，J. Med. Chem, 2021,11, 7468
Zhoujin, Y.; Zhang, M.; Parkin, S.; Li, T.; Yu, F.; Long, S. “A new solvate of clonixin and a comparison of the two clonixin solvates”, RSC Advances, 2021, 11, 24836
2020
Liu, H.; Yang, X.; Chen, J.; Zhang, M.; Parkin, S.; Cao, S.; Li, T.; Yang, Z.; Yu, F.; Long, S. “Steric effect determines the formation of lactam-lactam dimer or amide C=O...NH (lactam) chain motif in N-phenyl-2-hydroxynicotinanilides” Cryst. Growth Des. 2020, 20, 4346
Liu, H.; Yang, X.; Wu, S. Zhang, M.; Parkin, S.; Cao, S.; Li, T.; Yu, F.; Long, S. “An investigation of the polymorphism of a potent nonsteroidal anti-inflammatory drug flunixin” CrystEngComm 2020, 22, 448
Liu, H.; Long, S.; Rakesh, K. P.; Zha, G.-F. “ Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents” European Journal of Medicinal Chemistry, 2020, 185, 111804
2019
Liu, H.; Moku, B.; Li, F.; Ran, J.; Han, J.; Long, S.; Zha, G.-F.; Qin, H.-L. “Stereoselective construction of nitrile-substituted cyclopropanes from 2-substituted ethenesulfonyl fluorides via carbon-sulfur bond cleavage” Advanced Synthesis & Catalysis, 2019, 361(19), 4596
Liu, Y.; Zhang, M.; Xu, D.; Parkin, S.; Li, T.; Li, C.; Yang, Z.; Yu, F.; Long, S. “Effect of substituent size and isomerization on the polymorphism of 2-(naphthalenylamino)-benzoic acids” Crystal Growth & Design, 2019, 19(7), 3694
Zha, G.-F.; Rakesh, K. P.; Manukuma, H. M.; Shantharam, C. S.; Long, S. “Pharmaceutical significance of azepane based motifs for drug discovery: A critical review” European Journal of Medicinal Chemistry, 2019, 162, 465
学生获奖
2014 “海普瑞杯”第四届全国学生制药工程研究征文比赛 二等奖 （指导教师）
2015 “海普瑞杯”第五届全国学生制药工程研究征文比赛 二等奖 （指导教师）
2016 第九届药苑论坛 三等奖 （指导教师）
2016 研究生陈朋获国家奖学金
2017 研究生毛腾飞学位论文获校优秀硕士学位论文
2017 研究生刘梦获第七届全国学生制药工程研究征文比赛 一等奖 （指导教师）
2017 研究生刘梦获国家奖学金
2018 研究生刘梦优秀毕业研究生
2018 研究生刘梦学位论文获校优秀硕士学位论文
2018 研究生乐鹏云获国家奖学金，研究生彭思情获特等学业奖学金
2019 研究生乐鹏云,彭思情银河国际在线登录”学术之星”
2019 研究生彭思情优秀毕业研究生
2019研究生乐鹏云学位论文获校优秀硕士学位论文
2019研究生刘浩获国家奖学金
2020研究生刘浩优秀毕业研究生
2020研究生刘浩被美国南卡罗来纳大学全额奖学金录取为博士研究生
2020 研究生刘浩学位论文获校优秀硕士学位论文
2020 研究生杨星获国家奖学金
2021 研究生杨星学位论文获校优秀硕士学位论文
2021 研究生周金韵萍获国家奖学金
2022 研究生周金韵萍优秀毕业研究生
2020 研究生周金韵萍被美国明尼苏达大学全额奖学金录取为博士研究生
2022 研究生周金韵萍、陶洋、谢东学位论文获校优秀硕士学位论文
2023 研究生赵雪、黎玉萍、董冰倩学位论文获校优秀硕士学位论文
